Condition guide

Depression

When low mood stops lifting on its own

Overview

Major depressive disorder is more than sadness. It is a persistent change in mood, energy, thinking, and body function that lasts at least two weeks and interferes with daily life.

Depression is common, medical, and treatable. Roughly one in five adults experiences it at some point, and most people improve substantially with the right combination of therapy, lifestyle support, and — when needed — medication or TMS.

Common symptoms

  • Depressed mood most of the day, nearly every day
  • Loss of interest or pleasure in nearly all activities
  • Fatigue or loss of energy
  • Sleeping too much or too little
  • Appetite or weight change
  • Feelings of worthlessness or excessive guilt
  • Difficulty concentrating or making decisions
  • Psychomotor slowing or agitation
  • Thoughts of death or suicide

Causes and risk factors

  • Genetic vulnerability and family history
  • Dysregulation in mood-regulating brain networks, including the prefrontal cortex
  • Chronic stress, trauma, or prolonged adversity
  • Medical conditions such as thyroid disease, chronic pain, or sleep apnea
  • Substance use, including alcohol
  • Major loss, isolation, or life transition

Treatment options we offer

  • Individual therapy using CBT and behavioral activation
  • TMS therapy for depression that has not responded to medication
  • Coordination with your prescriber on medication management
  • Sleep, exercise, and routine interventions with real evidence behind them
  • Family involvement and support when helpful

Therapy approaches used

  • Cognitive Behavioral Therapy (CBT)
  • Behavioral activation
  • Trauma-informed therapy where trauma is a driver
  • Family and couples sessions

How TMS fits in

TMS is FDA-cleared for major depressive disorder and is the standard next step when one or more antidepressants have not produced adequate relief. It targets the left dorsolateral prefrontal cortex, is delivered without sedation, and adds no systemic medication side effects.

Learn more about TMS therapy

Frequently asked questions

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Tell us what you've tried. We'll confirm eligibility, verify your benefits, and map out what treatment would look like.